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人类多种恶性肿瘤可见到Ras基因的突变。Rap1(Ras-proximate1)是Ras家族中的一员,目前已分离出两种Rap1GTP酶激活蛋白:Rap1GAP及SPA-1(signal-inducedproliferation-associatedpro-tein-1)蛋白质家族。SPA-1是重要的Rap1GTP酶激活蛋白,对该基因的研究提示,它可能是一种肿瘤抑制基因。本文就SPA-1的研究现状作一综述。
A variety of human malignancies can be seen Ras gene mutations. Rap1 (Ras-proximate1) is a member of the Ras family. Two Rap1GTPase activating proteins have been isolated: Rap1GAP and SPA-1 (protein-inducedproliferation-associatedpro-tein-1) protein families. SPA-1 is an important Rap1GTPase activating protein. Studies on this gene suggest that SPA-1 may be a tumor suppressor gene. This article reviews the research status of SPA-1.