作者研究了几种聚甲基丙烯酰胺的抗矽肺活性。整个实验分为三个阶段。首先,用这些聚合物(50μg/ml)和石英粉尘(2mg/ml)加腹膜巨噬细胞培养物进行实验,根据其TTC还原酶活性的抑制程度来评价石英对巨噬细胞的破坏作用,并试验聚合物抑制石英引起红细胞悬浮液溶血作用的能力。结果筛选出两种具有抗细胞毒作用的化合物:其中作用较大的是聚-N,N-二甲胺基苯撑甲基丙烯酰胺-N-氧 The authors studied the anti-silicotic activity of several polymethacrylamides. The whole experiment is divided into three stages. First, experiments were performed with these polymer (50 μg / ml) and quartz dust (2 mg / ml) culture of peritoneal macrophages to evaluate the damaging effect of quartz on macrophages based on the degree of inhibition of TTC reductase activity and The test polymer inhibits quartz’s ability to cause hemolysis of erythrocyte suspensions. As a result, two compounds with anti-cytotoxic activity were screened out: Among them, poly-N, N-dimethylaminophenylacrylamide-N-oxide