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本文对23例由母婴传播所致无症状HBsAg 携带儿童(AHCC)作3～5年的随访观察,并以20例非母婴传播所致的同类儿童作为对照组,两组均经肝活组织检查.结果证实由HBsAg 阳性母亲在围产期传播所致的AHCC 比对照组较易引起肝实质的慢性损害,两组慢性肝病(CPH、CLH、CAH、CAHC)的形成率各为17/20(74%)、7/20(35%),P<0.05。从而强调了对HBsAg 阳性孕妇所分娩的婴儿必须立即给予注射乙肝高价免疫球蛋白和乙肝疫苗,这是降低慢性乙型肝炎的形成和阻止δ因子附加感染及原发性肝癌发病率的最有力措施。
In this study, 23 cases of asymptomatic HBsAg-bearing children (AHCC) caused by mother-to-child transmission were followed up for 3 to 5 years. Twenty children without CMV were used as control group, The results showed that the AHCC caused by perinatal transmission of HBsAg positive mothers was more likely to cause chronic liver damage than the control group. The incidence of chronic liver disease (CPH, CLH, CAH, CAHC) was 17 / 20 (74%), 7/20 (35%), P <0.05. It is emphasized that babies born to HBsAg-positive pregnant women must be given high-value hepatitis B immunoglobulin and hepatitis B vaccine immediately, which is the most powerful measure to reduce the formation of chronic hepatitis B and prevent the addition of delta-factor and the incidence of primary liver cancer .