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目的检测P53、Fas、Fasl在子宫内膜癌行放射治疗前后中的表达,探讨其与子宫内膜癌发生发展的关系及为放射治疗提供理论依据。方法采用免疫组化法检测2009年-2012年间在潍坊市妇幼保健院住院治疗的45例子宫内膜癌患者放射治疗前后P53、Fas、Fasl的表达情况。结果 (1)P53在子宫内膜癌中的表达放疗后较放疗前减弱,差异有统计学意义(P<0.05)(2)Fas在子宫内膜癌中的表达放疗后较放疗前增强,差异具有统计学意义(P<0.05)。(3)Fasl在子宫内膜癌中的表达放疗后较放疗前相差不大,差异无统计学意义(P>0.05)。结论 P53、Fas、Fasl与子宫内膜癌的发生密切相关,术前放疗增加了子宫内膜癌手术疗效。
Objective To detect the expressions of P53, Fas and Fasl before and after radiotherapy for endometrial carcinoma and explore their relationship with the occurrence and development of endometrial carcinoma and to provide a theoretical basis for radiotherapy. Methods Immunohistochemical method was used to detect the expression of P53, Fas and Fasl in 45 cases of endometrial cancer patients before and after radiotherapy hospitalized in Weifang Maternal and Child Health Hospital from 2009 to 2012. Results (1) The expression of P53 in endometrial carcinoma was weaker than that before radiotherapy, the difference was statistically significant (P <0.05) (2) The expression of Fas in endometrial carcinoma was significantly higher than that before radiotherapy Statistically significant (P <0.05). (3) Fasl expression in endometrial cancer after radiotherapy compared with before radiotherapy or less, the difference was not statistically significant (P> 0.05). Conclusion P53, Fas, Fasl are closely related to the occurrence of endometrial cancer. Preoperative radiotherapy increases the curative effect of endometrial cancer.