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目的 :探讨心力衰竭 (HF)患者血清脑钠素改变及其意义。方法 :放射免疫分析测定 88例HF(NYHAⅡ -Ⅳ级 )患者、2 0例心功能代偿期对照组 (NYHAⅠ级 )和 30例健康对照组的血清脑钠素水平 ,并进行对照分析。结果 :HF组总体血清脑钠素水平显著高于心功能处代偿期 (NYHAⅠ级 )组 (t=2 1 33,p <0 0 5 )和对照组 (t=2 335 ,p<0 0 5 ) ,NYHAⅡ级心功能时血BNP即显著高于对照组 (p <0 0 5 ) ,Ⅱ、Ⅲ、Ⅳ级组间血清BNP依次递增 (F =2 5 95 ,p<0 0 5 )。急性左心衰组血清BNP显著高于慢性心衰组 (t =2 2 6 8,p <0 0 5 ) ,而且缓解时血清BNP即显著下降 (p <0 0 5 )。结论 :测定血清脑钠素水平有助于HF患者发病机理、病情严重程度和预后的判断。
Objective: To investigate the changes of serum brain natriuretic peptide in patients with heart failure (HF) and its significance. Methods: Serum brain natriuretic peptide levels were measured in 88 patients with NYHA class Ⅱ-Ⅳ, 20 NYHA class Ⅰ patients and 30 healthy controls by radioimmunoassay. Results: The levels of total brain natriuretic peptide in HF group were significantly higher than those in NYHA class Ⅰ group (t = 2133, p <0.05) and control group (t = 2 335, p <0 0 5). BNP levels in NYHA class Ⅱ heart function group were significantly higher than those in control group (p <0.05). Serum BNP levels in groups Ⅱ, Ⅲ and Ⅳ were increased in turn (F = 2595, p <0.05). Serum BNP levels in patients with acute left heart failure were significantly higher than those in patients with chronic heart failure (t = 2.268, p <0.05), and serum BNP was significantly decreased at remission (p <0.05). Conclusion: Determination of serum brain natriuretic peptide contributes to the pathogenesis of HF, severity of disease and prognosis.