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目的探讨病毒感染所致的喘息性支气管炎患儿血清嗜酸性粒细胞趋化因子(Eotaxin)的检测及临床意义。方法选取本院2013年1月~2014年1月60例病毒感染所致的喘息性支气管炎患儿,且选取同时期健康体检儿童60例作为对照组,分析嗜酸性粒细胞趋化蛋白(Eotaxin)、单核细胞趋化蛋白-1(MCP-1)水平。结果轻度喘息组、重度喘息组相比较对照组Eotaxin、MCP-1明显上升,差异有统计学意义(P<0.05);急性期Eotaxin、MCP-1水平高于恢复期、临床痊愈期,差异有统计学意义(P<0.05)。结论血清嗜酸性粒细胞趋化蛋白与气道高反应程度具有正相关性,喘息性支气管炎测定血清嗜酸性粒细胞趋化蛋白检测能够判定疾病发生程度及临床分期。
Objective To investigate the serum eosinophil chemokines (Eotaxin) in children with asthmatic bronchitis caused by viral infection and its clinical significance. Methods Sixty children with asthmatic bronchitis caused by virus infection in our hospital from January 2013 to January 2014 were selected and 60 healthy children in the same period were selected as the control group. Eotaxin ), Monocyte chemotactic protein-1 (MCP-1) levels. Results The levels of Eotaxin and MCP-1 in mild asthmatic group and severe asthmatic group were significantly higher than those in control group (P <0.05), while the levels of Eotaxin and MCP-1 in acute asthmatic group were higher than those in recovery phase and clinical recovery phase There was statistical significance (P <0.05). Conclusions Serum eotaxin protein has a positive correlation with the degree of airway hyperresponsiveness. Serum eosinophil protein measured by asthmatic bronchitis can determine the degree and clinical stage of the disease.