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结核硬脂酸(TBSA)最初是由 Ander-_son 等从结核分支杆菌中分离而得,它是分支杆菌和其他放线菌属的一种结构成分,在正常人体组织中不含有此物。作者推出一种高度灵敏和快速的气相色谱-质谱测定/选择性离子监测法(GC-MS/SIM),用于测定脑脊液中的 TBSA,以诊断结核性脑膜炎。研究对象为13例经脑脊液(CSF)离心沉淀物镜检证实有抗酸杆菌(其中8例随后 CSF 培养出结核分支杆菌)而确诊为结核性脑膜炎的患者,以及9例经临床和CSF 检查疑诊为结核性脑膜炎的患者。在抗
TBSA, originally isolated from Mycobacterium tuberculosis by Ander-Johnson et al., Is a structural component of mycobacteria and other actinomycetes that are not found in normal human tissues. The authors have introduced a highly sensitive and rapid gas chromatography-mass spectrometry / selective ion monitoring (GC-MS / SIM) method for the determination of TBSA in cerebrospinal fluid to diagnose tuberculous meningitis. The study population consisted of 13 patients diagnosed as having tuberculous meningitis by acid-fast bacillus (eight of whom were subsequently CSF-cultured) by CSF sedimentation and nine by clinical and CSF tests Suspected of tuberculosis meningitis patients. In the anti