磷酸二酯酶7(phosphodiesterase7,PDE7)作为体内特异性水解第二信使环腺苷一磷酸(cyclic adenosine monophosphate,cAMP)的一类蛋白水解酶,通过调控组织细胞内cAMP水平及机体信号传导活动,参与了体内多种疾病的发生发展过程.PDE7主要分布于前炎症细胞及免疫细胞.最新研究表明,PDE7作为一个新的潜在的抗动脉粥样硬化及抗炎症免疫类药物的新靶点,其抑制剂可能在研究及治疗动脉粥样硬化及慢性阻塞性肺病等免疫炎症类疾病方面具有重要意义.本文简述PDE7基因结构、生物学功能以及其抑制剂研究,并重点就其与疾病之间联系做一综述. As a type of proteolytic enzyme that specifically hydrolyzes cyclic adenosine monophosphate (cAMP) in vivo, phosphodiesterase 7 (PDE7) regulates cAMP level and signal transduction activity in tissues, Is involved in the development and progression of many diseases in the body.PDE7 is mainly distributed in pro-inflammatory cells and immune cells.Recent studies have shown that PDE7 as a new potential anti-atherosclerotic and anti-inflammatory immune drugs, a new target, its Inhibitors may be of great importance in the study and treatment of immune-inflammatory diseases such as atherosclerosis and chronic obstructive pulmonary disease.This article briefly describes the structural, biological functions of PDE7 and its inhibitors, and focuses on its relationship with diseases Contact to make a review.