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目的观察肺结核患者在治疗期间出现肝功能异常情况,并对有效的处理方式进行探讨。方法共选择586例肺结核患者作为研究对象,对治疗期间出现肝功能异常情况的发生率及临床表现进行观察,并探讨预防和处理肝功能发生的有效措施。结果 586例患者共有82例发生肝功能异常情况,轻度肝功能异常60例(10.24%),中度肝功能异常21例(3.58%),重度肝功能异常1例(0.17%)。两个月末肝功能异常发生率为11.60%,超过2个月且直至疗程结束肝功能异常发生率为2.38%。结论肺结核患者在治疗期间出现肝功能异常情况发生率较高,但若早期发现并在护肝治疗基础上进行抗结核方案的调整,能够有效促使患者肝功能恢复,具有重要的研究意义。
Objective To observe the abnormal liver function of patients with pulmonary tuberculosis during the treatment, and to explore the effective treatment. Methods A total of 586 patients with pulmonary tuberculosis were selected as the research object. The incidence and clinical manifestations of abnormal liver function during treatment were observed, and the effective measures for prevention and treatment of liver function were discussed. Results A total of 82 cases of 586 patients had abnormal liver function, mild liver dysfunction in 60 cases (10.24%), moderate liver dysfunction in 21 cases (3.58%) and severe liver dysfunction in 1 case (0.17%). The incidence of abnormal liver function at the end of two months was 11.60%. After 2 months, the incidence of abnormal liver function was 2.38% at the end of the treatment period. Conclusions The incidence of abnormal liver function in patients with pulmonary tuberculosis is high. However, if the early detection and adjustment of anti-TB regimen based on hepatoprotective therapy can effectively promote the recovery of liver function, it is of great significance.