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[摘要] 目的 探讨格列美脲联合地特胰岛素治疗2型糖尿病疗效及安全性。 方法 选取2012年4月～2014年4月我院收治220例2型糖尿病患者，随机分为实验组与对照组，每组各110例。对照组患者予以格列美脲联合中性精蛋白锌人胰岛素进行治疗，实验组患者予以格列美脲联合地特胰岛素进行治疗，为期半年。治疗结束后，对两组患者的HbA1C、FBG、2h PG、0min C肽以及120min C肽进行测定、记录，另外对两组患者胰岛素的用量、血糖达标所需时间、体重增加值以及不良反应的发生情况进行统计记录。 结果 用药前，实验组患者与对照组患者HbA1C、FBG、2h PG比较差异无统计学意义（P>0.05）；用药后，两组患者的血糖水平均有所下降，以实验组下降更为显著，差异有统计学意义（P<0.05）；与对照组比较，实验组胰岛素用量低，血糖达标时间短，体重增加少，差异有统计学意义；实验组不良反应发生率较对照组低，为显著性差异（P<0.05）。 结论 格列美脲联合地特胰岛素治疗2型糖尿病，可快速有效的控制血糖，不良反应发生率低，安全性高，适宜于临床推广应用。
[关键词] 格列美脲；地特胰岛素；2型糖尿病
[中图分类号] R587.1 [文献标识码] B [文章编号] 2095-0616（2016）01-88-03
[Abstract] Objective To investgate efficacy and safety of Detemir combined with Glimepiride in the treatment of type 2 diabetes. Methods 220 cases who were diagnosed as type 2 diabetes patients in our hospital from April 2012 to April 2014 were selected， and devided into a control group and an observation group randomly， 110 cases in each group. The control group received Glimepirid combined with neutral protamine zinc human insulin ，the observation group received Glimepiride combined with Detemire for half a year. Before and after treatment， FBG、2hPG，HbA1C， FC-P、2hC-P 、weight of two groups were monitored and recorded， the standard time of blood glucose， incidence of side effect and insulin dosage are recorded. Results Before treatment， the differences of FBG， 2h PG， HbA1C， FC-P， 2hC-P between the two groups were not statistically significant （P>0.05）； after treatment， two groups of FBG， 2h PG and HbA1C， FC-P， 2hC-P decreased significantly， the difference was distinct （P<0.05）； the observation group decreased more than that in the control group， the difference was statistically significant （P<0.05）. The standard time of blood glucose， increasement and insulin dosage were lower than those in the control group， the differences were significant （P<0.05）；Incidence of side effect of observation group was lower than that of control group， the difference was palpable （P<0.05）. Conclusion A quick and distinct therapeutic effect is achieved in the treatment with glimepiride and detemir to T2DM， with a lower incidence of side effect. This technique is suitable for popularizing.
[Key words] Glimepiride； Detemir； Type 2 diabetes
近年来，随着人口老龄化的不断加剧，糖尿病已经逐渐成为一种临床上较为多见的疾病，其中以2型糖尿病为主。早期应用胰岛素对其进行治疗可有效的改善患者预后，但传统的胰岛素类似物常引起低血糖、体重增加等不良反应，地特胰岛素作为一种长效的降糖药在一定程度上减少不良反应的发生[1]。本院将格列美脲联合地特胰岛素用于治疗2型糖尿病，结果令人满意，现报道如下。
1 资料与方法
1.1 一般资料
选取2012年4月～2014年4月我院收治2型糖尿病患者220例为研究对象，随机分为实验组与对照组，每组各110例。其中实验组男63例，女47例，年龄（46.3±9.2）岁、病程（3.4±1.8）年；对照组男58例，女52例，年龄（44.9±9.7）岁，病程（3.1±2.0）年。所有患者均符合1999年WTO对T2DM的诊断标准，包括HbA1C>7.5%、FBG>8.0mmol/L、2hPBG>10.0mmol/L[2]。所有的患者均无严重的心、肝、肾功能不全，无精神病病史或磺胺类药物过敏史、均不处于妊娠期或哺乳期[3]。两组患者在性别、年龄上差异无统计学意义（P>0.05）.
[关键词] 格列美脲；地特胰岛素；2型糖尿病
[中图分类号] R587.1 [文献标识码] B [文章编号] 2095-0616（2016）01-88-03
[Abstract] Objective To investgate efficacy and safety of Detemir combined with Glimepiride in the treatment of type 2 diabetes. Methods 220 cases who were diagnosed as type 2 diabetes patients in our hospital from April 2012 to April 2014 were selected， and devided into a control group and an observation group randomly， 110 cases in each group. The control group received Glimepirid combined with neutral protamine zinc human insulin ，the observation group received Glimepiride combined with Detemire for half a year. Before and after treatment， FBG、2hPG，HbA1C， FC-P、2hC-P 、weight of two groups were monitored and recorded， the standard time of blood glucose， incidence of side effect and insulin dosage are recorded. Results Before treatment， the differences of FBG， 2h PG， HbA1C， FC-P， 2hC-P between the two groups were not statistically significant （P>0.05）； after treatment， two groups of FBG， 2h PG and HbA1C， FC-P， 2hC-P decreased significantly， the difference was distinct （P<0.05）； the observation group decreased more than that in the control group， the difference was statistically significant （P<0.05）. The standard time of blood glucose， increasement and insulin dosage were lower than those in the control group， the differences were significant （P<0.05）；Incidence of side effect of observation group was lower than that of control group， the difference was palpable （P<0.05）. Conclusion A quick and distinct therapeutic effect is achieved in the treatment with glimepiride and detemir to T2DM， with a lower incidence of side effect. This technique is suitable for popularizing.
[Key words] Glimepiride； Detemir； Type 2 diabetes
近年来，随着人口老龄化的不断加剧，糖尿病已经逐渐成为一种临床上较为多见的疾病，其中以2型糖尿病为主。早期应用胰岛素对其进行治疗可有效的改善患者预后，但传统的胰岛素类似物常引起低血糖、体重增加等不良反应，地特胰岛素作为一种长效的降糖药在一定程度上减少不良反应的发生[1]。本院将格列美脲联合地特胰岛素用于治疗2型糖尿病，结果令人满意，现报道如下。
1 资料与方法
1.1 一般资料
选取2012年4月～2014年4月我院收治2型糖尿病患者220例为研究对象，随机分为实验组与对照组，每组各110例。其中实验组男63例，女47例，年龄（46.3±9.2）岁、病程（3.4±1.8）年；对照组男58例，女52例，年龄（44.9±9.7）岁，病程（3.1±2.0）年。所有患者均符合1999年WTO对T2DM的诊断标准，包括HbA1C>7.5%、FBG>8.0mmol/L、2hPBG>10.0mmol/L[2]。所有的患者均无严重的心、肝、肾功能不全，无精神病病史或磺胺类药物过敏史、均不处于妊娠期或哺乳期[3]。两组患者在性别、年龄上差异无统计学意义（P>0.05）.