小儿误咽腐蚀剂的治疗仍是一个有争论和困难的问题。本文报道了美国哥伦布儿童医院70年代10年中对402例患儿的治疗经验。病理改变:酸引起组织凝固型坏死,并不穿透食管的深层,可致胃溃疡、穿孔或幽门狭窄。强硷引起液化型坏死,能穿透食管深部肌层,偶而导致穿孔。强硷灼伤引起的食管改变分为三个阶段:(1)急性坏死,由于细胞内蛋白质凝固而发生细胞死亡;(2)坏死区周围组织内发生强烈的炎性反应和血管内血栓形成;(3)在伤后2～4天表面的坏死层腐溃。临床方面,按灼伤程度分为轻、中和重度。轻度仅见粘膜红斑和/或水 The treatment of infantile vaginal erosions remains a controversial and difficult issue. This article reports the treatment experience of 402 children in Columbus Children’s Hospital in the United States in the 1970s. Pathological changes: Acid caused tissue coagulation necrosis, does not penetrate the deep esophagus, can cause gastric ulcer, perforation or pyloric stenosis. Strong alkaline cause liquefaction necrosis, can penetrate the deep esophageal muscle, and occasionally lead to perforation. Esophageal changes caused by strong alkali burns are divided into three stages: (1) acute necrosis, cell death due to intracellular protein coagulation; (2) intense inflammatory reactions and intravascular thrombosis within the tissues surrounding the necrotic area; ( 3) 2 to 4 days after injury necrotic layer surface rot. Clinical aspects, according to the degree of burn is divided into light, moderate and severe. Mucous erythema and / or water are seen only mildly