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目的研究原发性肝癌经肝动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)后肝癌组织中树突状细胞(DCs)浸润和VEGF表达的变化及其意义。方法选取经TACE治疗后二期手术切除的原发性肝癌病人标本17例(TACE组)和未经TACE单纯手术切除的原发性肝癌病人标本30例(单纯手术组),应用免疫组织化学方法检测肝癌组织中的树突状细胞含量及VEGF表达情况。结果TACE组标本中DCs数量明显少于单纯手术组(P<0.05);而其标本中VEGF表达明显强于单纯手术组(P<0.05)。结论TACE治疗后,肝癌组织中浸润的DCs数量明显减少与VEGF的表达增强有关,并可能是TACE后肝癌易复发、转移的重要原因之一。
Objective To investigate the changes and significance of dendritic cells (DCs) infiltration and VEGF expression in primary hepatocellular carcinoma after transcatheter arterial chemoembolization (TACE). Methods Seventeen TCC patients with primary hepatocellular carcinoma (HCC) resected by TACE and 30 patients with primary HCC without TACE were enrolled in this study. Immunohistochemistry Dendritic cells and VEGF expression in HCC tissues were detected. Results The number of DCs in TACE group was significantly less than that in the simple operation group (P <0.05). The VEGF expression in TACE group was significantly higher than that in the simple operation group (P <0.05). Conclusion After TACE treatment, the number of DCs infiltrating into hepatocellular carcinoma significantly decreased and the expression of VEGF increased, which may be one of the important reasons for the recurrence and metastasis of hepatocellular carcinoma after TACE.