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目的观察巴豆醛对雄性大鼠的肺损伤作用,探讨其毒作用机制。方法无特定病原体级健康雄性Wistar大鼠随机分为对照组和低、中、高剂量组,每组10只,分别予剂量为0.00、2.11、4.22和8.44 mg/kg体质量的巴豆醛溶液灌胃染毒,每天1次,连续25 d。末次染毒结束后处死大鼠,分离肺脏检测脏器系数并进行组织病理学检查,采用酶联免疫吸附实验测定肺组织中肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β、IL-4、IL-6和干扰素(IFN)-γ的水平。结果中和高剂量组大鼠肺组织均出现肺损伤的早期炎症性病理学改变,主要表现为肺泡结构破损、间隔增宽且有炎性细胞浸润、充血,细支气管上皮增厚、可见红细胞及炎性细胞浸润;高剂量组的改变更严重。大鼠肺脏脏器系数以及肺脏组织中IFN-γ、IL-4、IL-6、IL-1β、TNF-α水平均呈现随巴豆醛染毒剂量的增加而升高的剂量-效应关系(P<0.01)。结论巴豆醛可上调大鼠肺组织中炎性细胞因子水平,导致大鼠肺组织发生炎性损伤。
Objective To observe the effect of crotonaldehyde on lung injury in male rats and to explore its toxic mechanism. Methods Healthy male Wistar rats without specific pathogen were randomly divided into control group and low, medium and high dose groups, with 10 rats in each group. The rats were given crotonaldehyde solution of 0.00, 2.11, 4.22 and 8.44 mg / kg body weight respectively Stomach poisoning, 1 day, for 25 days. The rats were sacrificed at the end of the last exposure, and the organ coefficients of lung were separated and examined by histopathology. The levels of tumor necrosis factor-α, interleukin-1β, IL-4, IL-6 and interferon (IFN) -γ. Results In the middle and high dose groups, the early inflammatory pathological changes were observed in the lungs of the lungs. The main pathological changes of the lung tissues were damaged alveolar structures, broadened intervals, infiltration of inflammatory cells, hyperemia, thickening of the bronchial epithelium, red blood cells and inflammation Cell infiltration; high-dose group changes more serious. The lung organ coefficients and the levels of IFN-γ, IL-4, IL-6, IL-1β and TNF-α in lung tissue all showed a dose-response relationship with increasing dose of crotyl alcohol <0.01). Conclusion Crotonaldehyde can up-regulate the level of inflammatory cytokines in the lungs of rats, leading to inflammatory injury in rat lungs.