论文部分内容阅读
目的系统评价细辛脑注射液治疗呼吸系统疾病的有效性。方法计算机检索MEDLINE(1990～2010)、EMbase(1990～2010)、中文科技期刊全文数据库(1989～2010.1)、中国期刊全文数据库(1979～2009.12),收集有关细辛脑注射液治疗呼吸系统疾病的随机对照试验。由两名评价员独立地对纳入文献进行资料提取、质量评价并交叉核对,而后采用RevMan5.0软件进行Meta分析。结果共纳入文献29篇,包括3-931例患者。Meta分析结果显示:①细辛脑注射液可有效治疗毛细支气管炎、慢性阻塞性肺疾病(COPD)及其急性加重期,以及支气管炎、肺炎等呼吸系统疾病。②在治疗毛细支气管炎方面,细辛脑注射液总有效率优于氨茶碱、鱼腥草、病毒唑,与穿琥宁的疗效相似。③在治疗COPD及其急性加重期方面,细辛脑注射液总有效率优于COPD对症治疗、溴己新,与青霉素钠、复方甘草片疗效相似,其总有效率不如氨茶碱,但差异无统计学意义。④在治疗支气管炎方面,细辛脑注射液总有效率优于氨茶碱以及支气管炎的一般对症治疗,与沐舒坦疗效相似。⑤在治疗肺炎方面,细辛脑注射液总有效率优于抗生素、利巴韦林及氨茶碱。结论细辛脑注射液可有效治疗呼吸系统疾病。但由于纳入研究的方法学质量较低,可能存在发表性偏倚,因此需要进行更多高质量、大规模的临床随机对照研究,以便更客观、全面、正确地评价其疗效。
Objective To systematically evaluate the effectiveness of Asarone Injection in the treatment of respiratory diseases. Methods The data of MEDLINE (1990 ~ 2010), EMbase (1990 ~ 2010), Chinese Science and Technology Journals Full-text Database (1989 ~ 2010.1) and Chinese Journal Full-text Database (1979 ~ 2009.12) were collected. Randomized controlled trial. Two reviewers independently extracted data, evaluated the quality and cross-checked the data, and then used RevMan5.0 software to conduct meta-analysis. Results A total of 29 articles were included, including 3-931 patients. Meta-analysis showed that: Asarone injection can effectively treat bronchiolitis, chronic obstructive pulmonary disease (COPD) and its acute exacerbation, as well as respiratory diseases such as bronchitis and pneumonia. ② in the treatment of bronchiolitis, asarone injection total efficiency is better than aminophylline, Houttuynia, ribavirin, and chuanhuning similar efficacy. ③ In the treatment of COPD and its acute exacerbation, asarone injection total effective rate is better than COPD symptomatic treatment, bromhexine, and penicillin sodium, compound licorice tablets similar efficacy, the total efficiency is less than aminophylline, but the difference No statistical significance. ④ In the treatment of bronchitis, asarone injection is always better than aminophylline and bronchitis, the general symptomatic treatment, and Shu Shu Tan similar efficacy. ⑤ in the treatment of pneumonia, Asarone Injection is always better than antibiotics, ribavirin and aminophylline. Conclusion Asarone Injection can effectively treat respiratory diseases. However, because of the poor methodology involved in the study, there may be published bias, so more high-quality, large-scale randomized clinical trials are needed to evaluate their efficacy objectively, comprehensively and correctly.