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目的对比分析紫杉醇脂质体与传统紫杉醇联合卡铂治疗卵巢癌的疗效及不良反应。方法将92例晚期卵巢癌患者按照随机数字表法分为研究组和对照组,每组46例。研究组采用紫杉醇脂质体联合卡铂进行化疗;对照组采用传统紫杉醇联合卡铂进行化疗。对比2组治疗后临床疗效及治疗过程中不良反应发生情况。结果研究组总有效率为76.09%,对照组为69.57%,2组疗效对比差异无统计学意义(P>0.05);2组白细胞减少、血小板降低、血红蛋白减少、肾功能异常、腹泻、脱发、厌食的发生率对比,差异无统计学意义(P>0.05);研究组肌肉关节痛(4.35%)、呼吸困难(2.17%)、恶心呕吐(13.04%)、面部潮红(13.04%)、周围神经毒性(8.70%)、皮疹(4.35%)的发生率显著低于对照组(21.74%、15.22%、34.78%、36.96%、28.26%、19.57%),差异有统计学意义(χ~2=6.133、4.929、5.974、7.015、5.845、5.060,P<0.05)。结论紫杉醇脂质体与传统紫杉醇联合卡铂治疗卵巢癌的疗效相当,但紫杉醇脂质体的不良反应发生率显著低于传统紫杉醇。
Objective To compare the efficacy and side effects of paclitaxel liposomes with traditional paclitaxel combined with carboplatin in the treatment of ovarian cancer. Methods Ninety-two patients with advanced ovarian cancer were divided into study group and control group according to random number table method, with 46 cases in each group. The study group was treated with paclitaxel liposomes combined with carboplatin. The control group was treated with conventional paclitaxel combined with carboplatin. Compare the clinical efficacy of two groups after treatment and the occurrence of adverse reactions in the course of treatment. Results The total effective rate was 76.09% in the study group and 69.57% in the control group. There was no significant difference between the two groups (P> 0.05); the leukopenia, thrombocytopenia, hemoglobin decrease, renal dysfunction, diarrhea, The incidence of anorexia was no significant difference between the two groups (P> 0.05). In the study group, muscle joint pain (4.35%), dyspnea (2.17%), nausea and vomiting (13.04%), facial flushing The incidence of toxicity (8.70%) and rash (4.35%) was significantly lower than that of the control group (21.74%, 15.22%, 34.78%, 36.96%, 28.26%, 19.57% , 4.929, 5.974, 7.015, 5.845, 5.060, P <0.05). Conclusion paclitaxel liposomes with conventional paclitaxel combined carboplatin in the treatment of ovarian cancer is quite effective, but the incidence of adverse reactions paclitaxel liposomes was significantly lower than the traditional paclitaxel.