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目的检测原发性干燥综合征(pSS)患者血清中B淋巴细胞刺激因子(Blys)的表达水平,探讨其与pSS患者临床检测指标之间的关系及其在pSS发病中的作用。方法用酶联免疫吸附试验(ELISA)方法检测pSS患者血清中Blys的水平,并与患者的临床检测指标进行相关分析。结果pSS患者血清Blys水平为6．24ng/ml,而正常对照组仅为2．41ng/ml,两组间差异有统计学意义。另外,血清中Blys的水平与IgG的浓度及血沉有明显的相关性。结论pSS患者血清Blys的水平显著高于正常对照组,并与IgG的浓度及血沉相关。提示Blys可能通过激活特定的自身反应性B淋巴细胞,参与pSS的发病过程。
Objective To detect the expression of B lymphocyte stimulating factor (Blys) in the serum of patients with primary Sjogren’s Syndrome (pSS), and to explore its relationship with the clinical detection of pSS and its role in the pathogenesis of pSS. Methods Serum levels of Blys in patients with pSS were detected by enzyme-linked immunosorbent assay (ELISA), and the correlations were analyzed with the clinical parameters. Results The level of Blys in patients with pSS was 6.24ng / ml, compared with 2.41ng / ml in normal control group. The difference between the two groups was statistically significant. In addition, the level of serum Blys and IgG concentrations and erythrocyte sedimentation significantly correlated. Conclusion The level of serum Blys in patients with pSS is significantly higher than that in normal controls and is related to the concentration of IgG and erythrocyte sedimentation rate. These results suggest that Blys might participate in the pathogenesis of pSS by activating specific autoreactive B lymphocytes.