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【目的】研究不同配方的益生菌对小鼠肥胖所产生的影响。【方法】在高脂饮食诱导小鼠肥胖期间,给予不同配方的益生菌组合物,观察其对小鼠代谢所产生的影响,同时检测其肠道菌群。【结果】部分益生菌可引起小鼠体重增速加快,而部分益生菌配方可减缓小鼠肥胖和降低内脏脂肪重量,同时缓解高血脂。【结论】益生菌可影响小鼠体重和代谢,但不同配方的效果截然相反。特定的益生菌配方对肥胖和高血脂的改善可能是通过降低肠道中厚壁菌/拟杆菌比例以及升高Akkermansia muciniphila的含量造成的。此研究为进一步开发可改善代谢的益生菌产品奠定了基础。
【Objective】 To study the effect of different formula of probiotics on obesity in mice. 【Method】 During the period of obesity induced by high-fat diet, probiotics compositions with different formulations were given to observe their effects on metabolism in mice and to detect their intestinal flora. 【Result】 Some probiotics cause weight gain in mice. However, some probiotics can reduce obesity and visceral fat weight and alleviate hyperlipidemia in mice. 【Conclusion】 Probiotics can affect the body weight and metabolism of mice, but the effects of different formulas are the opposite. The improvement of obesity and hyperlipidemia by specific probiotic formulas may be caused by reducing the ratio of Fibrobacteria / Bacteriobacteria in the gut and increasing the content of Akkermansia muciniphila. This study lays the foundation for the further development of probiotic products that can improve metabolism.