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目的探讨人乳头状瘤病毒(HPV)感染与宫颈疾病发生的关系,为宫颈疾病的预防及其治疗提供依据。方法分析福建省仙游县妇幼保健院2006年7月-2011年6月60例不同类型宫颈疾病患者HPV的感染情况,结合病理诊断进行分析。结果 60例宫颈病变患者中宫颈炎37例,HPV感染率为29.7%;宫颈上皮内瘤变(CIN)23例,其中CINⅠ10例、CINⅡ7例、CINⅢ6例,感染率分别为60.0%、71.4%、83.3%,中高度CIN(CINⅡ、CINⅢ)感染率明显高于低度CIN和宫颈炎(P<0.05)。结论宫颈病变的发生、发展与HPV感染有关,随着病变程度的加重,HPV感染率明显增高,HPV检测可用于宫颈疾病的筛查及治疗后的随访。
Objective To investigate the relationship between human papillomavirus (HPV) infection and cervical diseases and to provide evidences for the prevention and treatment of cervical diseases. Methods The infection of HPV in 60 cases of different types of cervical diseases from July 2006 to June 2011 in Xianyou County Maternity and Child Care Hospital of Fujian Province was analyzed and analyzed with pathological diagnosis. Results Among the 60 patients with cervical lesions, 37 cases were cervicitis with HPV infection rate of 29.7%; 23 cases of cervical intraepithelial neoplasia (CIN), including 10 cases of CINⅠ, 7 cases of CINⅡ and 6 cases of CINⅢ. The infection rates were 60.0%, 71.4% 83.3%. The prevalence of CINⅡ and CINⅢ was significantly higher than that of low-grade CIN and cervicitis (P <0.05). Conclusions The incidence and development of cervical lesions are related to HPV infection. HPV infection is significantly increased with the severity of the lesions. HPV testing can be used to screen for cervical diseases and follow-up after treatment.