概念硬皮病广义上是皮肤发硬疾病的总称。临床上有在皮肤硬化的同时,内脏器官纤维化的疾病(全身性硬皮病、进行性全身性硬皮病).和仅限于皮肤硬化(局限性硬皮病)以及并发于基础疾病皮肤硬化者(假性硬皮病)等等。其发病可受职业或环境因素的影响,如职业性硬皮病等。说到硬皮病一般多指全身性硬皮病而言。硬皮病初发症状以雷诺氏现象为主,系原因不明的结缔组织疾病。病型分为轻重两型,前者四肢末端的皮肤硬化逐渐越过腕、足关节涉及躯干(肢端硬化病),后者除有雷诺氏现象外,以皮肤变硬、倦怠感、关节痛等为初期症状而急骤进展至全身水肿或水 The concept of scleroderma is broadly defined as a general term for hard skin disease. Clinically, there are diseases of sclerosis and systemic fibrosis (generalized scleroderma, progressive generalized scleroderma) and only for scleroderma (localized scleroderma) and concurrent with scleroderma of underlying diseases (Pseudo scleroderma) and so on. Its incidence may be affected by occupational or environmental factors, such as occupational scleroderma and so on. When it comes to scleroderma more generally refers to systemic scleroderma. The primary symptom of scleroderma is Raynaud’s phenomenon, which is an unknown connective tissue disease. The type of disease is divided into two types of severity, the former of the extremities gradually over the wrist skin sclerosis, foot joints involving the trunk (sclerosis), which in addition to Raynaud’s phenomenon, the skin hardens, burnout, joint pain, etc. The initial symptoms and rapid progress to systemic edema or water