论文部分内容阅读
客观合理地对口腔粘膜癌前变的严重程度作出分级，对预后及疗效有着至关重要的意义。为了提供准确诊断上皮异常增生分级的实验依据，实验采用二甲基苯并直（dimethylbenzanthracene，DMBA）诱导的金地鼠颊囊癌前病变模型标本，作光镜观察，依照WHO规定的诊断标准逐项记录。经过各项病理特征出现频率的研究发现，12项诊断标准能全面概括上皮异常增生各阶段的组织病理变化特点，其出现频率的高低，提示癌前病变的起始部位可能在基底层。异常核分裂象和丝分水平增加等二项特征在上皮异常增生分级诊断和判断预后中具有特殊意义。
Objectively and rationally to the severity of oral mucosal precancerous grading, prognosis and efficacy are of crucial significance. In order to provide an experimental basis for accurate diagnosis of epithelial dysplasia grade, the experimental model of precancerous lesion of hamster cheek pouch induced by dimethylbenzanthracene (DMBA) was observed by light microscopy and according to the diagnostic criteria defined by WHO recording. After the appearance of pathological features of the frequency of the study found that 12 diagnostic criteria for a comprehensive summary of epithelial dysplasia at different stages of the histopathological changes, the frequency of occurrence, suggesting that the precancerous lesion may be the beginning of the basal layer. Abnormal mitosis and silk sub-levels increased two characteristics such as the classification of epithelial dysplasia and prognosis of prognosis of special significance.