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目的探讨盖诺(NVB)联合顺铂治疗晚期非小细胞肺癌(NSCLC)的疗效及不良反应。方法31例Ⅲ~Ⅳ期非小细胞肺癌患者,应用盖诺25 mg/m2,iv,dl、d8,顺铂20mg/m2,静滴d1~5,3~4周为1周期,化疗2周后评价疗效。结果完全缓解3例,部分缓解11例,稳定13例,进展4例,有效率45.1%,不良反应主要为白细胞减少、静脉炎及恶心呕吐。结论盖诺联合顺铂治疗晚期非小细胞肺癌疗效确切,反应小,是治疗NSCLC的有效方案之一。
Objective To investigate the efficacy and adverse reactions of NVB plus cisplatin in the treatment of advanced non-small cell lung cancer (NSCLC). Methods 31 cases of stage Ⅲ ~ Ⅳ non-small cell lung cancer patients were treated with Gentamycin 25 mg / m 2, iv, dl, d8 and cisplatin 20 mg / m 2 intravenously for 1-3 weeks, After evaluation of efficacy. The results of complete remission in 3 cases, partial remission in 11 cases, stable in 13 cases, 4 cases of progress, the effective rate was 45.1%. The main adverse reactions were leukopenia, phlebitis and nausea and vomiting. Conclusions Gano combined with cisplatin in the treatment of advanced non-small cell lung cancer is effective and has a small response. It is an effective treatment for NSCLC.