对大鼠用高剂量(50mg/kg)及低剂量(30mg/kg)丙烯酰胺染毒后,于不同时期进行神经肌电及脊髓体感诱发电位的研究,发观大鼠中毒后股四头肌出现正锐波,坐骨神经运动神经传导速度减慢,脊髓体感诱发电位观察显示腰L_5、颈髓C_7诱发电位潜时延长,脊髓传导速度减慢,并显示剂量-反应关系,与丙烯酰胺中毒的“中枢-周围性远端型轴索病”的病理改变相符。 After the rats were treated with high dose (50mg / kg) and low dose (30mg / kg) acrylamide, the neuromuscular and spinal myoelectricity evoked potentials were studied at different stages, The incidence of positive R wave and slowing of the motor nerve conduction velocity of the sciatic nerve showed that the lumbar L_5 and the potential of C_7 evoked potentials were prolonged and the conduction velocity of the spinal cord was slowed down and the dose-response relationship was shown. Central - peripheral type distal axonal disease "consistent with the pathological changes.