血浆代用品是抢救休克的重要药剂,不论在平、战时均已广泛应用。目前国内外常用的各类代血浆,均有一定的缺点和局限性,如右旋醣酐生产条件要求高,生产周期长;使用后有出血倾向,有热原及抗原性质,体内蓄积、急性肾功能衰竭(低分子右旋醣酐‘及使网状内皮系统受损等缺点。又如羟乙基淀粉由于淀粉在羟乙基化时有聚环氧乙烷支链的形成而增加其副作用,引起渗血时间过长,网状内皮和肝细胞中蓄积,使肾小管 Plasma substitutes are important medicaments for rescuing shock, both in peace and wartime, and have been widely used. At present, all kinds of plasma substitutes commonly used at home and abroad have certain disadvantages and limitations, such as high dextran production conditions and long production cycle; bleeding after use, pyrogen and antigenic properties, accumulation in the body, acute Kidney failure (low molecular weight dextran ’) and the reticuloendothelial system, etc. As another example, hydroxyethyl starch has its side effects due to the formation of polyethylene oxide branches during hydroxyethylation , Causing bleeding time is too long, reticuloendothelial and hepatocyte accumulation, so that the renal tubules