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为了有效地保护高原低氧环境ＴＣＯ环境中作业工人的身心健康进行了本研究。在海拔１５０ｍ、２２６１ｍ、３４１７ｍ和４７５０ｍ４个不同地区采用标化小鼠急性染毒试验测定Ｌｃ５０，并在海拔２２６１ｍ和４７５０ｍ急性染毒后测定ＨｂＣＯ、ＰＯ＿２和ＳａＯ＿２；在海拔２３００ｍ对ＣＯ浓度２６．８／ｍ￣３环境中作业工人进行为期两年的流行病学调查。在４个海拔地区染毒小鼠的Ｌｃ５０分别５７１８ｐｐｍ、３４９２ｐｐｍ、３０７７ｐｐｍ和２２５４ｐｐｍ，三个高原地区毒性分别比平原增加０．６４倍、０．８６倍和１．５４倍；２２６１ｍ和４７５０ｍ染毒小鼠ＨｂＣＯ％值随染毒浓度增加而增大，ＰＯ＿２和ＳａＯ＿２下降（Ｐ＜０．０５）。接触２６．８ｍｇ／ｍ￣３ＣＯ作业工人阳性自觉症状发生率增多，神经行为功能改变，班后呼出气中ＣＯ浓度和ＨｂＣＯ含量提高，班后血胆固醇和血三脂增加，班后ＰＯ＿２和ＳａＯ＿２下降，与对照组比较差异有显著性意义。作者提出以高原地区实测ＣＯ的体积浓度与标准状态体积浓度的换算系数乘以国家卫生标准值为该地区ＣＯ卫生标准，建议海拔２０００～３０００ｍ地区为２０ｍｇ／ｍ￣２，３０００～４０００ｍ为１８ｍｇ／ｍ￣３。
This study was conducted in order to effectively protect the physical and mental health of workers in the TCO environment with high altitude and low oxygen environment. Lc50 was measured in four different areas of 150m, 2261m, 3417m and 4750m above sea level at the altitude of 2300m and CO concentration of 26.8 / M ~ 3 environment workers in a two-year epidemiological survey. The Lc50 of mice exposed to the four altitudes were 5718ppm, 3492ppm, 3077ppm and 2254ppm, respectively. The toxicity of the three plateau increased by 0.64 times, 0.86 times and 1.54 times respectively than that of the plain. The 2261m and 4750m The HbCO% of rats increased with the increase of exposure concentration, PO_2 and SaO_2 decreased (P <0.05). Exposure to 26.8mg / m ~ 3CO workers increased the incidence of positive symptoms, changes in neurobehavioral function, CO concentration and HbCO levels in the exhaled breath after the class increased, blood cholesterol and blood triglycerides increased after the shift, PO_2 and SaO_2 decreased after the shift , Compared with the control group, the difference was significant. The authors propose to multiply the measured coefficient of CO concentration in the plateau and the standard state volumetric concentration factor by the national health standard value for the CO standard in the area. It is suggested that the area should be 20mg / m ~ 2 at 2000 ~ 3000m and 18mg / m ~ 3.