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对507对欲作人工流产的夫妇进行断面调查及绒毛组织微核的测定,以探讨父母吸烟、饮酒及采取避孕措施等因素对子代的致突变性。结果显示:微核的发生率与母亲年龄、孕次、孕龄、既往流产史等自身的因素无关;各种避孕措施及少量饮酒均不具有诱发绒毛微核细胞率增加的作用。然而,男方吸烟、女方被动吸烟其微核细胞率为0.7645±0.0561‰高于饮酒组(0.5667±0.2004‰)和非吸烟对照组(05522±0.0616‰),与对照组有显著性统计学意义(P<0.05)。男方配偶吸烟兼饮酒者其微核发生率最高(0.7944±0.0754‰),说明吸烟与饮酒对诱发绒毛微核的产生有协同作用的趋势。本文并对男方吸烟和/或女方被动吸烟可诱发胚胎绒毛组织细胞DNA和/或纺锤体装置的损伤,进行了探讨,提出应引起人们的高度重视,并建议利用人类绒毛组织微核测定法作为监测环境致突变因子对人类下一代影响的方法。
A total of 507 pairs of couples who wish to make an abortion were surveyed and micronuclei of villous tissue were examined to explore the mutagenicity of offspring on factors such as smoking, drinking and contraceptive measures. The results showed that the incidence of micronuclei had no relation with their own factors such as mother’s age, gestational age, gestational age and previous abortion history. Various contraceptive measures and a small amount of alcohol consumption did not induce the increased rate of villus micronuclei. However, the rate of micronuclei in passive smoking of male was 0.7645 ± 0.0561 ‰ higher than that of drinking group (0.5667 ± 0.2004 ‰) and non-smoking control group (05522 ± 0.0616 ‰), which was significantly different from the control group P <0.05). The incidence of micronuclei in male spouse smoking and drinking was the highest (0.7944 ± 0.0754 ‰), indicating that smoking and drinking had a synergistic effect on induced micronuclei. In this paper, the smoking of man and / or female passive smoking can induce DNA damage in embryonic chorionic tissue cells and / or spindle device, and it is proposed that people should pay close attention to it. It is suggested that human villi tissue micronucleus test Methods to monitor the impact of environmental mutagens on human next generation.