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目的合成含有氨基和羧基的水溶性β－环糊精衍生物并测试其性能，这些化合物用作毛细管电泳添加剂．方法将β－环糊精与含有氨基的化合物在碱性条件下用环氧氯丙烷连接起来．结果合成了七（２，６－二－Ｏ－羧甲基）－β－环糊精（羧甲基－β－ＣＤ）、七｛２，６－二－Ｏ－［３－（２－氨基乙氨基）－２－羟丙基］｝－β－环糊精（乙二胺－β－ＣＤ）、七｛２，６－二－Ｏ－［３－（１，３－二羧基丙氨基）－２－羟丙基］｝－β－环糊精（谷氨酸－β－ＣＤ）、七｛２，６－二－Ｏ－［３－羧甲基氨基）－２－羟丙基〗｝－β－环糊精（甘氨酸－β－ＣＤ）、七｛２，６－二－Ｏ－［３－（１，２－二羧基乙氨基）－２－羟丙基］｝－β－环糊精（天冬氨酸－β－ＣＤ）、七｛２，６－二－Ｏ－［３－氨基－２－羟丙基）ｑ－β－环糊精（氨基－β－ＣＤ）、七｛２，６－二－Ｏ－［３－（２－羟基乙氨基）－２－羟丙基］｝－β－环糊精（乙醇氨－β－ＣＤ）等七种含有氨基和羧基的β－环糊精衍生物，结果表明它们具有良好的水溶性．将羧甲基－β－ＣＤ和谷氨酸－β－ＣＤ用作毛细管电泳添加剂分离了异丙嗪和扑尔敏两种手性异构体，得到了较好的分离结果．结论将氨基和羧基引入环糊精后可极大改善β－环糊精的水?
Aim To synthesize water soluble β-cyclodextrin derivatives containing amino and carboxyl groups and test their properties, these compounds are used as capillary electrophoresis additives. Methods β-Cyclodextrin and amino-containing compounds were linked with epichlorohydrin under basic conditions. Results Seven heptakis (2,6-di-O-carboxymethyl) -β-cyclodextrin (carboxymethyl-β-CD) Ethylamino) -2-hydroxypropyl]} - beta -cyclodextrin (ethylenediamine- [beta] -CD), hepta {2,6- di- O- [3- (1,3-dicarboxypropylamino) Hydroxypropyl]} - beta -cyclodextrin (glutamic acid-beta-CD), hepta {2,6- di- O- [3- carboxymethylamino) -2-hydroxypropyl} Β-cyclodextrin (glycine-β-CD), hepta {2,6-di-O- [3- (1,2-dicarboxyethylamino) -2-hydroxypropyl] (Aspartic acid -β-CD), hepta {2,6-di-O- [3 -amino-2-hydroxypropyl) q- Seven kinds of β-cyclodextrins with amino and carboxyl groups, such as 2,6-di-O- [3- (2-hydroxyethylamino) -2- hydroxypropyl] Cyclodextrin derivatives, the results show it It has good water solubility. The separation of two chiral isomers of promethazine and chlorpheniramine by using carboxymethyl-β-CD and glutamic acid-β-CD as capillary electrophoresis additives gave better separation results. Conclusion The introduction of amino and carboxyl groups can greatly improve the β-cyclodextrin water?