磷有机化合物的研究已经进行了一百多年了。它是元素有机化合物中最发展的一个。在二次世界大战以前,这一研究一直是脱离实际应用的,这其中作了很多重要的研究。主要的有两大学派:一个是德国A.Michaelis 学派,工作了四十年之久,主要研究了芳香族含磷化合物;另一个是俄国 A.E.学派,从1904年开始研究到现在已经50年,在(山客)山大学,主要研究脂肪族磷化合物——磷酸酯类。虽然他的工作并未得到实际应用,而他的合成方法是直到现在都被采用的。第二次世界大战以后,情况有了很大的改变,由于含磷有机化合物具有很强的生理活性,其中很多 Phosphorus organic compounds have been studied for over a hundred years. It is one of the most developed elemental organic compounds. Before World War II, this research has been out of practical application, which made a lot of important research. There are two main schools: one is the German A.Michaelis school, worked for 40 years, the main study of aromatic phosphorus compounds; the other is the Russian AE school, from 1904 to the present study has been 50 years, In (Shanke) Mountain University, the main study of aliphatic phosphorus compounds - phosphate esters. Although his work has not been put into practical use, his method of synthesis has been adopted until now. After the Second World War, the situation has changed a lot. Since phosphorus-containing organic compounds have strong physiological activity, many of them