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本文报导23例金盐所致血小板减少并分析其临床表现、治疗、转归及人白细胞抗原-D(HLA-DR)的分布。23例患者血小板减少病程在25年以上,有典型的类风湿关节炎。23例中女17,男6,年龄28～72岁,血小板数均<5万。21例类风湿因子(+),其中20例胶乳定影滴度为1;160以上。23例血小板减少者,17例起病急,2例起病缓慢,4例未能确定。金盐治疗者,每周应用18例,隔周应用4例,每月应用1例。23例患者除血小板减少外还合并其他毒性表现,如蛋白尿(5/23),口腔炎或皮炎(5/23),嗜酸性粒细胞增
This article reports 23 cases of gold salt-induced thrombocytopenia and analysis of its clinical manifestations, treatment, outcome and distribution of human leukocyte antigen-D (HLA-DR). 23 patients with thrombocytopenia over 25 years, with typical rheumatoid arthritis. 23 cases of female 17, male 6, aged 28 to 72 years, the number of platelets were <50,000. 21 cases of rheumatoid factor (+), of which 20 cases of latex fixation titer of 1; 160 or more. 23 cases of thrombocytopenia, 17 cases of acute onset, 2 cases of slow onset, 4 cases failed to determine. Golden salt treatment, weekly application of 18 cases, 4 cases every other week, 1 case of application per month. In addition to thrombocytopenia, 23 patients had other toxic manifestations such as proteinuria (5/23), stomatitis or dermatitis (5/23), eosinophilia