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目的:分析维持性泼尼松治疗视神经脊髓炎的临床疗效及安全性。方法:选取2015年1月至2016年4月河源市人民医院收治的100例复发型视神经脊髓炎患者,随机分成两组,各50例。对照组服用硫唑嘌呤片治疗,观察组应用维持性口服泼尼松方式治疗,统计比较两组患者治疗前、治疗后扩展残疾状态量表(EDSS)评分、年复发率、疗效及不良反应情况。结果:治疗前,两组患者EDSS评分比较,差异无统计学意义(P>0.05);治疗后,两组患者EDSS评分均改善明显,且观察组低于对照组,差异具有统计学意义(P<0.05);观察组年复发率低于对照组,临床疗效高于对照组,不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论:维持性泼尼松治疗视神经脊髓炎能够有效改善患者神经功能,降低年复发率与不良反应。
Objective: To analyze the clinical efficacy and safety of maintenance prednisone in the treatment of optic neuromyelitis. Methods: One hundred patients with recurrent optic neuritis treated in Heyuan People’s Hospital from January 2015 to April 2016 were selected and randomly divided into two groups (n = 50 in each group). The patients in the control group were treated with azathioprine tablets. The patients in the observation group were treated with sustained oral prednisone. The EDSS scores, annual recurrence rates, curative effects and adverse reactions of the two groups were compared before and after treatment . Results: Before treatment, there was no significant difference in EDSS score between the two groups (P> 0.05). After treatment, the EDSS scores of both groups improved significantly, and the observation group was lower than the control group, the difference was statistically significant (P <0.05). The annual recurrence rate in the observation group was lower than that in the control group, and the clinical efficacy was higher than that in the control group. The incidence of adverse reactions was lower than that in the control group. The difference was statistically significant (P <0.05). CONCLUSION: Maintenance of prednisone for optic neuromyelitis can effectively improve the neurological function, reduce the annual recurrence rate and adverse reactions.