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AIM:To investigate the effect of famotidine ongastroesophageal reflux(GER)and duodeno-gastro-esophageal reflux(DGER)and to explore it’s possiblemechanisms.To identify the relevant factors of the reflux.METHODS:Ninteen critically ill patients were consecutivelyenrolled in the study.Dynamic 24 hours monitoring of GERand DGER before and after administration of famotidine wasperformed.The parameters of gastric residual volume,multiPle organ disorder syndrome(MODS)score,acutephysiology and chronic health evaluation Ⅱ(APACHE Ⅱ)scoreand PEEP were recorded.Paired ttest;Wilcoxon signedranks test and Univariate analysis with Spearman’s rankcorrelation were applied to analyse the data.RESULTS:Statistical significance of longest acid reflux,reflux time of pH<4 and fraction time of acid reflux wasobserved in ten critically ill patients before and afteradministration.Pvalue is 0.037,0.005,0.005 respectively.Significance change of all bile reflux parameters wasobserved before and after administration.Pvalue is 0.007,0.024,0.005,0.007,0.005.GER has positive correlationwith APACHE Ⅱ score and gastric residual volume withcorrelation coefficient of 0.720,0.932 respectively.CONCLUSION:GER and DGER are much improved afterthe administration of famotidine.GER is correlated withAPACHE Ⅱ score and gastric residual volume.
AIM: To investigate the effect of famotidine ongastroesophageal reflux (GER) and duodeno-gastro-esophageal reflux (DGER) and to explore it’s possible mechanisms. To identify the relevant factors of the reflux. METHODS: Ninteen critically ill patients were consecutively committed in the study. Dynamic 24 hours monitoring of GER and DGER before and after administration of famotidine wasperformed. The parameters of gastric residual volume, multiPle organ disorder syndrome (MODS) score, acutephysiology and chronic health evaluation II (APACHE II) score and PEEP were recorded. Paired ttest; Wilcoxon signedranks test and univariate analysis with Spearman’s rankcorrelation were applied to analyze the data.RESULTS: Statistical significance of longest acid reflux, reflux time of pH <4 and fraction time of acid reflux wasobserved in ten critically ill patients before and afteradministration. P value is 0.037, 0.005, 0.005 respectively. Significance change of all bile reflux parameters wasobserved before and after administra .Pvalue is 0.007,0.024,0.005,0.007,0.005.GER has positive correlation with APACHE II score and gastric residual volume withcorrelation coefficient of 0.720,0.932 respectively.CONCLUSION: GER and DGER are much improved afterthe administration of famotidine. GER is correlated with APACHE Ⅱ score and gastric residual volume.