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成人微小病变型(MCD)肾病综合征仅有80%对激素敏感。但常多次复发,从激素敏感转为激素依赖,持续或重复的激素治疗不可避免地发生并发症。伴有局灶节段性肾小球硬化(FSGS)者仅有10%对激素敏感,对激素治疗无效的病人常发展到终末期肾衰,应用烷化剂治疗也有副作用且缓解在40%以下。有研究发现应用环孢素A治疗对激素或细胞毒药物无效的病人取得了一些效果。为了观察环孢素A的疗效和耐受性,作者对成人特发性肾病综合征进行了治疗。研究分两组,一组64例病人:单独应用环孢素A治疗,三月后观察疗效;二组48例病人,环孢素
Only 80% of adults with minimally pathological (MCD) nephrotic syndrome are hormone-sensitive. However, many times recurrence, from hormone-sensitive to hormone-dependent, continuous or repeated hormone therapy inevitable complications. Only 10% of patients with focal segmental glomerulosclerosis (FSGS) are hormone-sensitive, patients who do not respond to hormonal therapy often develop end-stage renal failure, and alkylating agents have side effects and relief of less than 40% . Some studies have found that cyclosporin A treatment of hormone or cytotoxic drugs ineffective in patients with some results. In order to observe the efficacy and tolerability of cyclosporin A, the authors treated adult idiopathic nephrotic syndrome. The study was divided into two groups, a group of 64 patients: cyclosporine A alone treatment, efficacy was observed after March; two groups of 48 patients, cyclosporine