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目的对桦甸市829名儿童的抗HAV、HBsAg和ALT检测结果进行分析,从而确定健康人群。方法采用整群随机抽样的方法,对1～3年级学生和学前班儿童进行体检和问卷调查,选择既往无甲肝病史和甲肝疫苗接种史的人群作为研究对象,检测其血液中抗HAV、HBsAg和ALT的情况。结果通过对829名学生进行检测,3项均为正常者为710名。结论通过检测,确定了健康人群,为评价疫苗的安全性、免疫原性,比较儿童接种不同类型甲肝疫苗后不同时间抗体水平变化,以及应急接种方案确定了研究对象。
Objective To analyze the detection results of anti-HAV, HBsAg and ALT in 829 children in Huadian City to determine the healthy population. Methods A cluster random sampling method was used to conduct physical examination and questionnaire survey on children in grade 1 to grade 3 and preschool children. The subjects who had no prior history of hepatitis A and the history of hepatitis A vaccination were selected as subjects to detect their anti-HAV, HBsAg and ALT Case. The results of 829 students through the test, three were normal to 710. Conclusions Through the test, the healthy population was determined to evaluate the safety and immunogenicity of the vaccine, to compare the antibody levels at different time points after the children were vaccinated with different types of hepatitis A vaccine, and the emergency vaccination program to determine the subjects.