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本文旨在探讨人参皂苷Rg_1体外对金葡菌感染肺上皮细胞所致病变的作用及其可能的机制。实验采用体外大鼠原代肺上皮细胞感染模型。RT-PCR和Western blot方法观察肺细胞中integrinβ1,NF-κB和糖皮质激素受体(GR)等相关因子的表达。结果表明人参皂苷Rg_1可以明显抑制金葡菌感染后肺上皮细胞整合素integrinβ1的表达,下调炎性因子NF-κB,ICAM-1,TNF-α,IL-2和IL-6,上调GR的表达。人参皂苷Rg_1可以明显抑制金葡菌感染肺上皮细胞后的炎性因子,从而对肺脏起到一定的保护作用。
This article aims to investigate the effect of ginsenoside Rg_1 on the pathological changes induced by staphylococcus aureus in lung epithelial cells in vitro and its possible mechanism. In vitro experiments using primary rat lung epithelial cell infection model. The expression of integrinβ1, NF-κB and glucocorticoid receptor (GR) and other related factors in lung cells were observed by RT-PCR and Western blot. The results showed that ginsenoside Rg_1 could significantly inhibit the expression of integrinβ1 in lung epithelial cells after S.aureus infection, and downregulate the expression of GR (NF-κB, ICAM-1, TNF-α, IL-2 and IL-6) . Ginsenoside Rg_1 can significantly inhibit the inflammatory factors after S. aureus infection of lung epithelial cells, which play a protective effect on the lungs.