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目的:研究和探讨偏头痛与缺血性卒中的相关性以及抗磷脂抗体在偏头痛相关性卒中发病中的作用。方法:运用问卷调查方式统计普通人群及脑梗死患者偏头痛的患病率,将脑梗死患者按有否偏头痛病史分为两组,用ELISA方法分别测定其血清抗心磷脂抗体(anticardiolipinantibodies,ACA)水平。结果:①脑梗死患者偏头痛的患病率与普通人群偏头痛的患病率分别为20.0%和6.0%,二者之间差异有显著性意义(χ2=13.2671,P<0.01)。②脑梗死伴有偏头痛史者和无偏头痛史者,其ACA阳性率分别为41.7%和19.5%,二者差异具有显著性意义(χ2=5.0133,P<0.05)。结论:偏头痛病史与脑梗死具有明显相关性。抗磷脂抗体可能参与偏头痛所相关的脑梗死的发病机制。
OBJECTIVE: To study and explore the correlation between migraine and ischemic stroke and the role of antiphospholipid antibodies in migraine-associated stroke. Methods: The prevalence of migraine in the general population and patients with cerebral infarction was calculated by means of questionnaire. The patients with cerebral infarction were divided into two groups according to their history of migraine. The serum levels of anticardiolipin antibodies (ACA )Level. Results: ①The prevalence of migraine in patients with cerebral infarction was 20.0% and 6.0% respectively compared with the general population (χ2 = 13.2671, P <0.01). The positive rate of ACA was 41.7% and 19.5% respectively in patients with history of migraine with history of migraine and without history of migraine, the difference was significant (χ2 = 5.0133, P <0.05). Conclusion: The history of migraine has a significant correlation with cerebral infarction. Antiphospholipid antibodies may be involved in the pathogenesis of migraine-related cerebral infarction.