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目的了解近年来急性乙型肝炎的临床及流行病学情况。方法用SPSS13.0对384例急性乙型肝炎病人的临床资料进行统计学分析。结果18～45岁为高发年龄段占78.7%,汉族占98.2%,79.4%患者传播途径不详;男性发病人数高于女性,比例为3.99:1;临床治愈好转率较高(98.9%)。暴发性肝炎发病率0.5%。发病后半年内随访血中HBsAg转阴率97.1%,HBVDNA转阴率98.5%,急性乙型肝炎慢性化率2.9%。结论乙型肝炎的发病年龄及传播途径已经发生明显变化;急性乙型肝炎的治愈好转率较高,但有极少数病人会发生慢性化及重型化。
Objective To understand the clinical and epidemiological status of acute hepatitis B in recent years. Methods The clinical data of 384 patients with acute hepatitis B were analyzed by SPSS 13.0. Results The age of 18 to 45 years was 78.7% in the high incidence age group, 98.2% in the Han nationality, and 79.4% in the Han nationality was unknown. The incidence of males was higher than that of the females (3.99: 1), and the cure rate was higher (98.9%). The incidence of fulminant hepatitis 0.5%. Follow-up within six months after onset of blood HBsAg negative rate of 97.1%, HBVDNA negative rate of 98.5%, acute hepatitis B chronic rate of 2.9%. Conclusion The age of onset of hepatitis B and the route of transmission have changed significantly. The cure rate of acute hepatitis B is higher, but there are very few cases of chronic hepatitis B and severe disease.