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目的研究恶性间皮瘤与p16蛋白表达的关系。方法利用微波煮沸脱交联SP法,对34例恶性间皮瘤病理标本进行了p16蛋白表达的研究。结果p16蛋白阳性表达率53%(18/34),47%(16/34)的病例细胞内缺乏p16蛋白的表达。多数存在p16蛋白表达的病例没有发现p53基因的点突变;反之,存在p53基因的点突变的病例多数都没有p16蛋白的表达。p16蛋白表达与p53基因点突变之间呈明显的负相关关系。结论恶性间皮瘤可能同时存在p53和p16基因的异常,肿瘤组织细胞内缺乏p16蛋白的表达可能与p16基因的纯合缺失有关。
Objective To study the relationship between malignant mesothelioma and the expression of p16 protein. Methods The expression of p16 protein in 34 cases of malignant mesothelioma was studied by microwave boiling de-crosslinking SP method. Results The positive rate of p16 protein expression was 53% (18/34), and 47% (16/34) cases lacked the expression of p16 protein. Most of the cases with p16 protein expression did not find point mutations in the p53 gene; conversely, most cases with point mutations in the p53 gene did not have p16 protein expression. There was a significant negative correlation between p16 protein expression and p53 gene point mutation. Conclusion There may be abnormal p53 and p16 genes in malignant mesothelioma at the same time. The lack of p16 protein expression in tumor tissue may be related to homozygous deletion of p16 gene.