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通过离体皮肤渗透释药实验，选择促酮基布洛芬（ＫＰ）凝胶透皮吸收的最佳氮酮（Ａｚｏｎｅ）浓度。本实验证实，３～５％Ａｚｏｎｅ对２．５％ＫＰ凝胶有非常明显的促渗透作用，６～８ｈ即可使ＫＰ透皮释放率达到５０％以上，可以认为３～５％的Ａｚｏｎｅ是配制ＫＰ外用制剂较为适宜的浓度范围。
The optimum Azone concentration for transdermal absorption of ketoprofen (KP) gel was selected by ex vivo skin penetration drug release assay. This experiment confirmed that 3 ~ 5% Azone has a very obvious promoting effect on 2.5% KP gel, 6 ~ 8h can make KP transdermal release rate above 50%, it can be considered that 3 ~ 5% Azone is Preparation of KP topical formulations more appropriate concentration range.