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目的:分析肺结核患者对氯法齐明的耐药情况。方法:回顾性分析2015年1月至2018年6月首都医科大学附属北京胸科医院结核科1 770例肺结核患者的病例资料,其中男1 225例,女545例,年龄8~92(43.2±15.2)岁。采用比例法药物敏感试验(简称药敏试验)对结核菌株进行抗结核药物耐药性检测,计数资料采用χ2检验或Fisher精确检验。结果:1 770例结核患者中,对氯法齐明敏感患者1 713例,耐药患者57例,耐药率为3.2%(57/1 770),其中复治患者氯法齐明耐药率明显高于初治患者[5.8%(38/656)比1.7%(19/1 114),χ2=22.129,n P=0.000];多耐药、耐多药及广泛耐药患者对氯法齐明耐药率分别为1.0%(17/1 770)、1.2%(21/1 770)、1.1%(19/1 770);有住院史的耐氯法齐明的耐多药及广泛耐药患者耐药率2.4%(14/594)、2.7%(16/594)分别高于无住院史的患者0.6%(7/1 176)、0.3%(3/1 176),差异均有统计学意义(χ2=10.447、22.099,n P=0.001、<0.001)。n 结论:肺结核患者对氯法齐明的耐药率较低,可提高耐药肺结核病患者治疗成功率,具有较好的应用价值。“,”Objective:To analyze the drug resistance of tuberculosis patients to clofazimine.Methods:Retrospective analysis was conducted on the case data of 1 770 tuberculosis patients in Department of tuberculosis, Beijing Chest Hospital affiliated to Capital Medical University from January 2015 to June 2018, including 1 225 males and 545 females, aged 8-92 (43.2±15.2) years old. Drug sensitivity tests using proportion method (hereinafter referred to as drug susceptibility test) for TB strains anti-tb drug resistance test. Using χn 2 test or Fisher′s exact test.n Results:1 770 cases of tuberculosis patients, 1 713 cases of patients with clofazimine sensitive, of 57 patients with drug resistance, and resistant rate was 3.2% (57/1 770), including patients with recurrent clofazimine, significantly higher than the initial percentages of patients [5.8% (38/656), 1.7% (19/1 114), χ2= 22.129, n P = 0.000, n P<0.01]; The drug resistance rates of poly-resistant, multi-drug resistant and extensively resistant patients to clofazimine were 1.0% (17/1 770), 1.2% (21/1 770) and 1.1% (19/1 770), respectively. Has a history of hospitalization of clofazimine resistance of multidrug-resistant and extensively drug-resistant patients resistant rate 2.4% (14/594), 2.7% (16/594), respectively, higher than 0.6% (7/1 176) with no history of hospitalized patients, 0.3% (3/1 176), the differences were statistically significant (χ2=10.447,22.099,n P=0.001,<0.001).n Conclusion:Clofazimine has a low resistance rate, which can improve the treatment success rate of patients with drug-resistant tuberculosis and has important value.