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目的观察局部雾化吸入布地奈德、利巴韦林与全身应用布地奈德和利巴韦林治疗小儿急性喉炎的效果及不良反应,探讨联合吸入布地奈德混悬液及利巴韦林治疗小儿急性喉炎的疗效。方法选择本院2007年1月-2008年11月住院及门诊确诊急性喉炎患儿96例,随机分为常规静脉组(A组),布地奈德单一雾化组(B组),布地奈德和利巴韦林联合雾化组(C组)。观察比较3组患儿治疗效果。结果C组与A组治愈率比较有显著性差异(χ2=19.79P<0.05);C组与B组治愈率比较有显著性差异(χ2=5.14P<0.05)。C组咳嗽、声嘶、喉鸣音消失时间和住院时间均较A组及B组显著缩短(Pa<0.05)。结论布地奈德混悬液联合利巴韦林雾化吸入治疗小儿急性喉炎效果明显,不良反应小。
Objective To observe the effect and adverse reactions of local inhalation of budesonide, ribavirin and systemic administration of budesonide and ribavirin in the treatment of acute laryngitis in children and explore the effect of combined inhalation of budesonide suspension and ribavirin Therapeutic effect of acute laryngitis in children. Methods A total of 96 children with acute laryngitis diagnosed in our hospital from January 2007 to November 2008 were randomly divided into two groups: conventional venous group (group A), budesonide single atomized group (group B), budesonide Germany and ribavirin joint atomization group (C group). Observation and treatment of children with 3 groups were compared. Results The cure rates of group C and group A were significantly different (χ2 = 19.79P <0.05). The cure rates of group C and group B were significantly different (χ2 = 5.14P <0.05). C group cough, hoarseness, the disappearance of laryngeal sounds and hospital stay were significantly shorter than those in group A and group B (P <0.05). Conclusion Budesonide suspension combined with ribavirin aerosol inhalation treatment of acute laryngitis in children with obvious effect, small adverse reactions.