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目的制备双嘧达莫片剂并研究该片剂生物利用度。方法采用超声沉淀法结合高压均质技术制备粒径为300 nm双嘧达莫纳米混悬剂,以喷雾干燥法对其进行固化,用扫描电镜(scanning e-lectron microscope,SEM)观察粒子形态,差示扫描热分析法(differential scanning calorimetry,DSC),X射线衍射(X-ray diffraction analysis,XRD)和红外光谱法分析喷干粉末中药物的存在状态和与稳定剂之间相互作用。通过粉末直接压片法制备双嘧达莫片剂,并与市售普通片相比较,测定双嘧达莫片剂相对生物利用度。结果药物以晶体形式存在于片剂中,且溶出度显著提高,相对生物利用度为185%。结论采用纳米技术分散双嘧达莫后,所制备的片剂能够提高药物在家犬体内的生物利用度。
OBJECTIVE To prepare dipyridamole tablets and study the tablet bioavailability. Methods A suspension of 300 mg dipyridamole was prepared by ultrasonic precipitation and high pressure homogenization. The suspension was cured by spray drying. The morphology of the particles was observed by scanning electron microscopy (SEM) Differential scanning calorimetry (DSC), X-ray diffraction (XRD) and infrared spectroscopy were used to analyze the existing state of the drug in the spray-dried powder and the interaction with the stabilizer. Dipyridamole tablets were prepared by powder compression directly, and the relative bioavailability of dipyridamole tablets was determined in comparison with the commercial tablets. Results The drug was present in the form of crystals in tablets with a marked increase in dissolution and a relative bioavailability of 185%. Conclusion The nanometer technology disperse dipyridamole, the prepared tablet can improve the bioavailability of drugs in dogs.