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吉非贝齐是降血脂新药,其化学结构式为5—(2,5—二甲苯氧基)—2,2—二甲基戊酸。是对氯苯氧异丁酸乙酯的同系物,但其差别是没有卤化,所以长期应用副作用很小。其降血脂作用的机理:提高脂蛋白脂酶活性,增强甘油三酯(TG)、低密度脂蛋白(LDL)和极低密度脂蛋白(VLDL)的分解代谢,促进胆固醇(ch)从胆汁排泄,从而使LDL和VLDL浓度降低,高密度脂蛋白(HDL)水平升高。
Gemfibrozil lipid-lowering drugs, the chemical formula for 5- (2,5-dimethylphenoxy) -2,2-dimethylpentanoic acid. Is chlorophenoxy ethyl isobutyrate homologue, but the difference is not halogenated, so long-term use of side effects is small. The mechanism of its hypolipidemic effect is to increase lipoprotein lipase activity, enhance the catabolism of triglyceride (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL), and promote the excretion of cholesterol (ch) from bile , Resulting in lower concentrations of LDL and VLDL and elevated levels of high-density lipoprotein (HDL).