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目的:探讨脑出血(ICH)患者血管紧张素原(AGT)T704C基因多态性及二者的相关性。方法:采用病例—对照研究,结合聚合酶链反应—限制性片断长度多态性(PCR-RFLP)技术检测70例ICH患者和89例健康体检者的AGT T704C单核苷酸多态性,并将ICH组按是否合并高血压而分为两组:高血压组和非高血压组。比较和分析ICH与对照组间该基因型及等位基因的分布频率差异,并分析该遗传因素对ICH的作用。结果:ICH组704CC基因型频率41.4%,C等位基因频率67.1%,与对照组比较,差异无统计学意义(P>0.05)。结论:AGT T704C基因多态性可能与ICH的发生无关。
Objective: To investigate the polymorphism of angiotensinogen (AGT) T704C gene in patients with intracerebral hemorrhage (ICH) and their correlation. METHODS: AGT T704C single nucleotide polymorphisms (SNPs) of 70 patients with ICH and 89 healthy controls were detected by case-control study and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) The ICH group was divided into two groups according to whether the hypertension was combined: hypertension group and non-hypertension group. To compare and analyze the frequency distribution of genotype and allele between ICH and control group, and analyze the effect of this genetic factor on ICH. Results: The frequency of 704CC genotype was 41.4% in ICH group and 67.1% in C allele. There was no significant difference between the two groups (P> 0.05). Conclusion: The AGT T704C gene polymorphism may not be related to the occurrence of ICH.