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该研究为确定血管紧张素Ⅱ(angiotensin,AngⅡ)是否通过诱导Akt和FOXO3a的磷酸化以影响大鼠心脏成纤维细胞线粒体抗氧化锰超氧化物歧化酶(manganese superoxide dismutase,Mn-SOD)mRNA和蛋白的表达,从而影响心肌进行氧化应激。方法 :从正常成年
This study was designed to determine whether angiotensin (AngⅡ) affects the mitochondrial manganese superoxide dismutase (Mn-SOD) mRNA and protein levels in cardiac fibroblasts by inducing the phosphorylation of Akt and FOXO3a Protein expression, thus affecting myocardial oxidative stress. Method: From normal adulthood