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《Oncology Times》1984;6(2):10. 圣安东尼奥消息,美国细胞生物学学会的会议中有一篇报告称,钙通道阻滞剂的抗血小板作用对于抑制肿瘤转移可能有一定的效用。一项研究表明,给与硝苯吡啶或Nimodipine的小鼠与未给药的对照小鼠比较,前者可抑制80—85％转移性肿瘤。生理学家、底特律韦恩州立大学肿瘤生物学部的放射肿瘤学系副研究员James M Onoda向《肿瘤学时报》的记者说,已讨论了临床试验的可能性。 Onoda发现,在试管内,硝苯吡啶和Nimodipine抑制肿瘤细胞和血小板相互间的作
Oncology Times, 1984; 6(2): 10. San Antonio, a report from the American Society of Cell Biology reported that the antiplatelet effect of calcium channel blockers may have some utility in inhibiting tumor metastasis. One study showed that mice given nifedipine or Nimodipine can inhibit 80-85% of metastatic tumors compared to untreated control mice. The physiologist, James M Onoda, associate professor of radiation oncology at Wayne State University’s Department of Cancer Biology, Detroit, told the Oncology Times reporter that the possibility of a clinical trial has been discussed. Onoda found that in vitro, nifedipine and Nimodipine inhibit the interaction between tumor cells and platelets.