制备13-表甾族化合物,一般都用光化学法,即以紫外光照射17-酮-甾族化合物而得,采用这种方法,不仅需要具有一定要求的光源设备,而且操作繁复,收率低。最近,R.B.Boar等将17-酮肟在醋酐、吡啶中回流进行还原酰化,生成13-表烯酰胺和13-表烯亚胺的平衡混合物,通过氧化铝柱层析,转变为单一的烯酰胺,收率85％。此烯酰胺 The preparation of 13-epi- steroids is generally carried out photochemically by irradiating the 17-keto-steroid with ultraviolet light. In this method, not only light source apparatus having certain requirements but also complicated operation and low yield . Recently, RB Boar et al 17-ketoxime refluxed in acetic anhydride and pyridine to undergo reductive acylation to produce a balanced mixture of 13-epienamide and 13-epiminimide, which was converted to a single Enamide in 85% yield. This enamide