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据报道,卵巢癌中染色体22q上的LOH发生率在25％～71％之间。作者以前的研究认为卵巢癌中的肿瘤抑制基因位于D22S283末端,即对应于22q12-qter。作者使用8种多形性微小卫星体标志物研究了染色体22q上LOH与卵巢癌的相关性,并定义了LOH的最小区域。58/110例显示1个或多个位点的LOH,这些肿瘤中典型的缺失为两个独特的LOH区域,一个位于D22S284和CYP2D之间,约0.5cM的遗传学距离,第2个邻近D27S276的侧
It has been reported that the incidence of LOH on chromosome 22q in ovarian cancer is between 25% and 71%. The authors previous study suggested that the tumor suppressor gene in ovarian cancer is located at the end of D22S283, which corresponds to 22q12-qter. The authors used eight polymorphic microsatellite markers to investigate the association of LOH with ovarian cancer on chromosome 22q and to define the smallest region of LOH. 58/110 showed LOH at one or more sites, typical of these tumors were two distinct LOH regions, one located between D22S284 and CYP2D at a genetic distance of about 0.5 cM, the second adjacent to D27S276 The side