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目的 :观察糖尿病合并肺结核患者外周血T淋巴细胞亚群变化 ,并探讨其在糖尿病继发肺结核发生发展中的作用。方法 :用间接免疫荧光法测定 2 7例糖尿病合并肺结核患者 ,31例糖尿病患者 ,34例肺结核患者及 2 5例正常人外周血CD+ 3 、CD+ 4和CD+ 8T淋巴细胞数量 ,并测定其空腹血糖。结果 :糖尿病合并肺结核患者及糖尿病患者外周血CD+ 3 T淋巴细胞明显低于健康人 (P <0 0 5 ) ,但CD+ 8T淋巴细胞则显著高于正常人 (P <0 0 1) ,而且CD+ 8T淋巴细胞与空腹血糖呈明显正相关关系 (P <0 0 5 )。结论 :CD+ 8T淋巴细胞的增多在糖尿病继发肺结核的发病机制中起着重要的作用
Objective: To observe the changes of T lymphocyte subsets in peripheral blood of diabetic patients with pulmonary tuberculosis and to explore its role in the development of secondary pulmonary tuberculosis. Methods: The numbers of CD + 3, CD + 4 and CD + 8 T lymphocytes in peripheral blood of 27 cases of diabetic patients with pulmonary tuberculosis, 31 cases of diabetic patients, 34 cases of pulmonary tuberculosis and 25 normal controls were measured by indirect immunofluorescence method. The fasting blood glucose . Results: CD + 3 T lymphocytes in diabetic patients with pulmonary tuberculosis and diabetes were significantly lower than those in healthy people (P <0.05), but CD + 8 T lymphocytes were significantly higher than those in normal controls (P <0.01) 8T lymphocytes and fasting blood glucose showed a significant positive correlation (P <0 05). Conclusion: Increased CD + 8 T lymphocytes play an important role in the pathogenesis of secondary pulmonary tuberculosis in diabetes