口腔粘膜的灶性上皮增生被Archard等于1965年首先报告病因不明。Clausen等通过电子显微镜观察,发现灶性上皮增生的标本中有病毒样微粒。作者对两例灶性上皮增生的活检材料进行了研究。组织学上主要的变化为棘皮症、乳头瘤病。基底层和棘层内出现许多胞浆透明的细胞。电子显微镜观察,基底层和棘层内发现有 Focal epithelial hyperplasia of the oral mucosa was first reported by Archard et al. in 1965 for an unknown cause. Clausen et al. observed electron microscopy and found that there were virus-like particles in specimens with focal epithelial hyperplasia. The authors studied two biopsy materials with focal epithelial hyperplasia. The major histological changes are acanthosis and papillomatosis. There are many cytoplasmic and transparent cells in the basal and stratum spinosum. Electron microscope observations were found in the basal and spinous layers