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目的 观察联合使用一氧化氮 (NO)和腺苷 (AD)对肺动脉高压的影响。方法 选用上海种白猪 10头 ,建立急性缺氧性肺动脉高压模型 ,采用分别使用吸入NO 2 0× 10 -6和静脉持续每分钟滴注AD 5 0 μg/kg体重 ,以及联合使用NO和AD的方式 ,在各时段进行各项血流动力学指标测定。结果 联合使用NO和AD ,平均肺动脉压力从 (37± 7)mmHg(1mmHg =0 .133kPa)降至 (2 0± 1)mmHg(P <0 .0 1) ,心排指数从 (2 .30± 0 .5 0 )L·min-1·m-2 升至 (2 .76± 0 .46 )L·min-1·m-2 (P <0 .0 5 )。结论 NO和AD联合治疗幼猪急性缺氧性肺动脉高压 ,在降低肺动脉压力的同时 ,还可增加心输出量。
Objective To observe the effects of combined use of nitric oxide (NO) and adenosine (AD) on pulmonary hypertension. Methods Acute hypoxic pulmonary hypertension model was established by using 10 species of Shanghai white pigs. Adopting inhalation of NO 2 0 × 10 -6 and intravenous continuous drip infusion of AD 5 0 μg / kg body weight per minute respectively, and the combination of NO and AD Way, in each period for the determination of hemodynamic indicators. Results Combined use of NO and AD decreased mean pulmonary artery pressure from (37 ± 7) mmHg (1 mmHg = 0.133 kPa) to (20 ± 1) mmHg (P <0.01) ± 0.50) L · min-1 · m-2 to (2.76 ± 0.46) L · min-1 · m-2 (P <0.05). Conclusion NO and AD combined with acute hypoxic pulmonary hypertension in neonatal rats can decrease the pulmonary artery pressure and increase cardiac output.