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目的 研究猪胰腺十二指肠移植术后胰腺和十二指肠粘膜急性排斥反应的病理变化特点及它们之间的关系。方法 12头猪作同种异体胰腺十二指肠移植 ,平均分为未用药组和治疗组 ,术后定期取胰腺和十二指肠粘膜作普通病理检查。结果 胰腺急性排斥反应时首先并持续损伤腺泡 ,以后累及胰腺导管 ,最后为胰岛和血管。胰腺和十二指肠粘膜急性排斥反应大多同时存在 ;间质性排斥反应评分相同者占 73% ,评分不同者中 ,胰腺评分较高 ,占 5 8.3%。结论 胰腺十二指肠移植后急性排斥反应最先累及胰腺外分泌系统 ;最终累及内分泌组织。十二指肠粘膜活检有助于确定有无胰腺急性排斥反应 ,但不能确定其严重程度。
Objective To study the pathological characteristics of acute rejection of pancreas and duodenal mucosa after porcine pancreas duodenum transplantation and their relationship. Methods 12 pigs were allotransplantated for allogeneic pancreas. The rats were equally divided into the untreated group and the treatment group. The pancreas and duodenal mucosa were taken for routine pathological examination after operation. Results Pancreatic acute rejection first and continued to damage the acinus, later involving the pancreatic duct, and finally to the islets and blood vessels. Acute rejection of the pancreas and duodenal mucosa mostly existed at the same time; 73% of patients with the same score of interstitial rejection had higher scores of pancreatic cancer (8.33%) than those with different scores. Conclusions Acute rejection after pancreaticoduodenectomy is the first to involve the pancreatic exocrine system; eventually involving the endocrine tissue. Duodenal mucosal biopsy can help determine the presence or absence of pancreatic acute rejection but can not determine its severity.